Bioavailability and hepatoprotection enhancement of berberine and its nanoparticles prepared by liquid antisolvent method

The study was devised to prepare berberine nanoparticles by anti-solvent precipitation method and were assessed for their hepatoprotective effect in Male Sprague-Dawley rats against carbon tetrachloride. pharmacokinetic parameters of the prepared evaluated rabbits. Histopathological studies blood biochemical analyses carried out evaluate role both forms experimental animals. Substantial improvement liver function test enzymes levels histopathology achieved animals treated with comparison unprocessed whereas, nanoform about 3.97 3.88 folds higher than that berberine. revealed reduction particle size nano range improved provided better protection high concentration. Thus, pharmacokinetics effects observed form form.